A Polymorphism at Position 400 in the Connection Subdomain of HIV-1 Reverse Transcriptase Affects Sensitivity to NNRTIs and RNaseH Activity

Reverse transcriptase (RT) plays an essential role in HIV-1 replication, and inhibition of this enzyme is a key component of HIV-treatment. However, the use of RT inhibitors can lead to the emergence of drug-resistant variants. Until recently, most clinically relevant resistance mutations were found...

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Bibliographic Details
Main Authors: Wright, David W., Deuzing, Ilona P., Flandre, Philippe, van den Eede, Peter, Govaert, Micheline, Setiawan, Laurentia, Coveney, Peter V., Marcelin, Anne-Geneviève, Calvez, Vincent, Boucher, Charles A. B., Beerens, Nancy
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788777/
https://ncbi.nlm.nih.gov/pubmed/24098331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074078
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