Modification of Hematopoietic Stem/Progenitor Cells with CD19-Specific Chimeric Antigen Receptors as a Novel Approach for Cancer Immunotherapy

Chimeric antigen receptors (CARs) against CD19 have been shown to direct T-cells to specifically target B-lineage malignant cells in animal models and clinical trials, with efficient tumor cell lysis. However, in some cases, there has been insufficient persistence of effector cells, limiting clinica...

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Main Authors: De Oliveira, Satiro Nakamura, Ryan, Christine, Giannoni, Francesca, Hardee, Cinnamon L., Tremcinska, Irena, Katebian, Behrod, Wherley, Jennifer, Sahaghian, Arineh, Tu, Andy, Grogan, Tristan, Elashoff, David, Cooper, Laurence J.N., Hollis, Roger P., Kohn, Donald B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Mary Ann Liebert, Inc. 2013
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787487/
https://ncbi.nlm.nih.gov/pubmed/23978226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.202
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