Modification of Hematopoietic Stem/Progenitor Cells with CD19-Specific Chimeric Antigen Receptors as a Novel Approach for Cancer Immunotherapy

Chimeric antigen receptors (CARs) against CD19 have been shown to direct T-cells to specifically target B-lineage malignant cells in animal models and clinical trials, with efficient tumor cell lysis. However, in some cases, there has been insufficient persistence of effector cells, limiting clinica...

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Detalhes bibliográficos
Main Authors: De Oliveira, Satiro Nakamura, Ryan, Christine, Giannoni, Francesca, Hardee, Cinnamon L., Tremcinska, Irena, Katebian, Behrod, Wherley, Jennifer, Sahaghian, Arineh, Tu, Andy, Grogan, Tristan, Elashoff, David, Cooper, Laurence J.N., Hollis, Roger P., Kohn, Donald B.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787487/
https://ncbi.nlm.nih.gov/pubmed/23978226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.202
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