Modification of Hematopoietic Stem/Progenitor Cells with CD19-Specific Chimeric Antigen Receptors as a Novel Approach for Cancer Immunotherapy

Chimeric antigen receptors (CARs) against CD19 have been shown to direct T-cells to specifically target B-lineage malignant cells in animal models and clinical trials, with efficient tumor cell lysis. However, in some cases, there has been insufficient persistence of effector cells, limiting clinica...

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Bibliografiske detaljer
Main Authors: De Oliveira, Satiro Nakamura, Ryan, Christine, Giannoni, Francesca, Hardee, Cinnamon L., Tremcinska, Irena, Katebian, Behrod, Wherley, Jennifer, Sahaghian, Arineh, Tu, Andy, Grogan, Tristan, Elashoff, David, Cooper, Laurence J.N., Hollis, Roger P., Kohn, Donald B.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2013
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787487/
https://ncbi.nlm.nih.gov/pubmed/23978226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.202
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