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A Mathematical Model of the Effect of Immunogenicity on Therapeutic Protein Pharmacokinetics
A mathematical pharmacokinetic/anti-drug-antibody (PK/ADA) model was constructed for quantitatively assessing immunogenicity for therapeutic proteins. The model is inspired by traditional pharmacokinetic/pharmacodynamic (PK/PD) models, and is based on the observed impact of ADA on protein drug clear...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer US
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3787236/ https://ncbi.nlm.nih.gov/pubmed/23990500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-013-9517-z |
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