A Mechanistic, Multiscale Mathematical Model of Immunogenicity for Therapeutic Proteins: Part 1—Theoretical Model

A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins was formulated by recapitulating key biological mechanisms, including antigen presentation, activation, proliferation, and differentiation of immune cells, secretion of antidrug antibodies (ADA), as well as in vi...

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Autors principals: Chen, X, Hickling, T P, Vicini, P
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211265/
https://ncbi.nlm.nih.gov/pubmed/25184733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2014.30
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