Proline Substitution of Dimer Interface β-strand Residues as a Strategy for the Design of Functional Monomeric Proteins

Proteins that exist in monomer-dimer equilibrium can be found in all organisms ranging from bacteria to humans; this facilitates fine-tuning of activities from signaling to catalysis. However, studying the structural basis of monomer function that naturally exists in monomer-dimer equilibrium is cha...

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Hlavní autoři: Joseph, Prem Raj B., Poluri, Krishna Mohan, Gangavarapu, Pavani, Rajagopalan, Lavanya, Raghuwanshi, Sandeep, Richardson, Ricardo M., Garofalo, Roberto P., Rajarathnam, Krishna
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2013
Témata:
Proteins and Nucleic Acids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785864/
https://ncbi.nlm.nih.gov/pubmed/24048001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.08.008
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