Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation

Chaperone–usher pathway pili are a widespread family of extracellular, Gram-negative bacterial fibers with important roles in bacterial pathogenesis. Type 1 pili are important virulence factors in uropathogenic Escherichia coli (UPEC), which cause the majority of urinary tract infections (UTI). FimH...

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Autors principals: Schwartz, Drew J., Kalas, Vasilios, Pinkner, Jerome S., Chen, Swaine L., Spaulding, Caitlin N., Dodson, Karen W., Hultgren, Scott J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785778/
https://ncbi.nlm.nih.gov/pubmed/24003161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315203110
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