Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions

Positive selection in the two-domain type 1 pilus adhesin FimH enhances Escherichia coli fitness in urinary tract infection (UTI). We report a comprehensive atomic-level view of FimH in two-state conformational ensembles in solution, composed of one low-affinity tense (T) and multiple high-affinity...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Kalas, Vasilios, Pinkner, Jerome S., Hannan, Thomas J., Hibbing, Michael E., Dodson, Karen W., Holehouse, Alex S., Zhang, Hao, Tolia, Niraj H., Gross, Michael L., Pappu, Rohit V., Janetka, James, Hultgren, Scott J.
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2017
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302871/
https://ncbi.nlm.nih.gov/pubmed/28246638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601944
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