Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions

Positive selection in the two-domain type 1 pilus adhesin FimH enhances Escherichia coli fitness in urinary tract infection (UTI). We report a comprehensive atomic-level view of FimH in two-state conformational ensembles in solution, composed of one low-affinity tense (T) and multiple high-affinity...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Kalas, Vasilios, Pinkner, Jerome S., Hannan, Thomas J., Hibbing, Michael E., Dodson, Karen W., Holehouse, Alex S., Zhang, Hao, Tolia, Niraj H., Gross, Michael L., Pappu, Rohit V., Janetka, James, Hultgren, Scott J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302871/
https://ncbi.nlm.nih.gov/pubmed/28246638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601944
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