Blockade of the purinergic P2Y(12) receptor greatly increases the platelet inhibitory actions of nitric oxide

Circulating platelets are constantly exposed to nitric oxide (NO) released from the vascular endothelium. This NO acts to reduce platelet reactivity, and in so doing blunts platelet aggregation and thrombus formation. For successful hemostasis, platelet activation and aggregation must occur at sites...

Full description

Saved in:
Bibliographic Details
Main Authors: Kirkby, Nicholas S., Lundberg, Martina H., Chan, Melissa V., Vojnovic, Ivana, Solomon, Antonia B., Emerson, Michael, Mitchell, Jane A., Warner, Timothy D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785756/
https://ncbi.nlm.nih.gov/pubmed/24003163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218880110
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items