Protein Kinase CK2 Inhibition Down Modulates the NF-κB and STAT3 Survival Pathways, Enhances the Cellular Proteotoxic Stress and Synergistically Boosts the Cytotoxic Effect of Bortezomib on Multiple Myeloma and Mantle Cell Lymphoma Cells

CK2 is a pivotal pro-survival protein kinase in multiple myeloma that may likely impinge on bortezomib-regulated cellular pathways. In the present study, we investigated CK2 expression in multiple myeloma and mantle cell lymphoma, two bortezomib-responsive B cell tumors, as well as its involvement i...

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Main Authors: Manni, Sabrina, Brancalion, Alessandra, Mandato, Elisa, Tubi, Laura Quotti, Colpo, Anna, Pizzi, Marco, Cappellesso, Rocco, Zaffino, Fortunato, Di Maggio, Speranza Antonia, Cabrelle, Anna, Marino, Filippo, Zambello, Renato, Trentin, Livio, Adami, Fausto, Gurrieri, Carmela, Semenzato, Gianpietro, Piazza, Francesco
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785505/
https://ncbi.nlm.nih.gov/pubmed/24086494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075280
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