Inactivation of CK1α in multiple myeloma empowers drug cytotoxicity by affecting AKT and β-catenin survival signaling pathways

Recent evidence indicates that protein kinase CK1α may support the growth of multiple myeloma (MM) plasma cells. Here, by analyzing a large cohort of MM cases, we found that high CK1α mRNA levels are virtually associated with all MM patients. Moreover, we provided functional evidence that CK1α activ...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Manni, Sabrina, Carrino, Marilena, Manzoni, Martina, Gianesin, Ketty, Nunes, Sara Canovas, Costacurta, Matteo, Tubi, Laura Quotti, Macaccaro, Paolo, Taiana, Elisa, Cabrelle, Anna, Barilà, Gregorio, Martines, Annalisa, Zambello, Renato, Bonaldi, Laura, Trentin, Livio, Neri, Antonino, Semenzato, Gianpietro, Piazza, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362429/
https://ncbi.nlm.nih.gov/pubmed/28099937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14654
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