Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity

BACKGROUND: The involvement of protein kinase CK2 in sustaining cancer cell survival could have implications also in the resistance to conventional and unconventional therapies. Moreover, CK2 role in blood tumors is rapidly emerging and this kinase has been recognized as a potential therapeutic targ...

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Main Authors: Quotti Tubi, Laura, Gurrieri, Carmela, Brancalion, Alessandra, Bonaldi, Laura, Bertorelle, Roberta, Manni, Sabrina, Pavan, Laura, Lessi, Federica, Zambello, Renato, Trentin, Livio, Adami, Fausto, Ruzzene, Maria, Pinna, Lorenzo A, Semenzato, Gianpietro, Piazza, Francesco
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2013
נושאים:
Research
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852751/
https://ncbi.nlm.nih.gov/pubmed/24283803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-6-78
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