Protein Kinase CK2 Inhibition Down Modulates the NF-κB and STAT3 Survival Pathways, Enhances the Cellular Proteotoxic Stress and Synergistically Boosts the Cytotoxic Effect of Bortezomib on Multiple Myeloma and Mantle Cell Lymphoma Cells

CK2 is a pivotal pro-survival protein kinase in multiple myeloma that may likely impinge on bortezomib-regulated cellular pathways. In the present study, we investigated CK2 expression in multiple myeloma and mantle cell lymphoma, two bortezomib-responsive B cell tumors, as well as its involvement i...

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Asıl Yazarlar: Manni, Sabrina, Brancalion, Alessandra, Mandato, Elisa, Tubi, Laura Quotti, Colpo, Anna, Pizzi, Marco, Cappellesso, Rocco, Zaffino, Fortunato, Di Maggio, Speranza Antonia, Cabrelle, Anna, Marino, Filippo, Zambello, Renato, Trentin, Livio, Adami, Fausto, Gurrieri, Carmela, Semenzato, Gianpietro, Piazza, Francesco
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785505/
https://ncbi.nlm.nih.gov/pubmed/24086494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075280
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