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Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget’s disease of bone

Paget’s disease is characterized by highly localized areas of increased osteoclast (OCL) activity. This suggests that the microenvironment in pagetic lesions is highly osteoclastogenic, or that OCL precursors in these lesions are hyperresponsive to osteoclastogenic factors (or both). To examine thes...

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Udgivet i:J Clin Invest
Principais autores: Menaa, Cheikh, Reddy, Sakamuri V., Kurihara, Noriyoshi, Maeda, Hidefumi, Anderson, Dirk, Cundy, Tim, Cornish, Jillian, Singer, Frederick R., Bruder, Jan M., Roodman, G. David
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2000
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC378510/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10862799/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9133
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