PDZ-RhoGEF is essential for CXCR4-driven breast tumor cell motility through spatial regulation of RhoA

The CXCL12–CXCR4 chemokine signaling pathway is a well-established driver of cancer progression. One key process promoted by CXCR4 stimulation is tumor cell motility; however, the specific signaling pathways leading to migration remain poorly understood. Previously, we have shown that CXCL12 stimula...

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Bibliografiske detaljer
Main Authors: Struckhoff, Amanda P., Rana, Manish K., Kher, Swapnil S., Burow, Matt E., Hagan, Joseph L., Del Valle, Luis, Worthylake, Rebecca A.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784824/
https://ncbi.nlm.nih.gov/pubmed/23868972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.132381
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