Clinical and laboratory studies of the novel cyclin-dependent kinase inhibitor dinaciclib (SCH 727965) in acute leukemias

PURPOSE: Dinaciclib inhibits cyclin-dependent kinases 1, 2, 5, and 9 with a better therapeutic index than flavopiridol in preclinical studies. This study assessed the activity of dinaciclib in acute leukemia both in the clinic and in vitro. METHODS: Adults with relapsed/refractory acute myeloid leuk...

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Hlavní autoři: Gojo, Ivana, Sadowska, Mariola, Walker, Alison, Feldman, Eric J., Iyer, Swaminathan Padmanabhan, Baer, Maria R., Sausville, Edward A., Lapidus, Rena G., Zhang, Da, Zhu, Yali, Jou, Ying-Ming, Poon, Jennifer, Small, Karen, Bannerji, Rajat
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2013
Témata:
Clinical Trial Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784060/
https://ncbi.nlm.nih.gov/pubmed/23949430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-013-2249-z
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