A first-in-human, phase 1, dose-escalation study of dinaciclib, a novel cyclin-dependent kinase inhibitor, administered weekly in subjects with advanced malignancies

BACKGROUND: Dinaciclib, a small-molecule, cyclin-dependent kinase inhibitor, inhibits cell cycle progression and proliferation in various tumor cell lines in vitro. We conducted an open-label, dose-escalation study to determine the safety, tolerability, and bioactivity of dinaciclib in adults with a...

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Autors principals: Nemunaitis, John J, Small, Karen A, Kirschmeier, Paul, Zhang, Da, Zhu, Yali, Jou, Ying-Ming, Statkevich, Paul, Yao, Siu-Long, Bannerji, Rajat
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853718/
https://ncbi.nlm.nih.gov/pubmed/24131779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-259
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