CREATING A “PRO-SURVIVAL” PHENOTYPE THROUGH EPIGENETIC MODULATION

BACKGROUND: We have recently demonstrated that treatment with suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, significantly improves survival in a rodent model of lipopolysaccharide (LPS)-induced endotoxic shock. However, the precise mechanisms have not been well defined. Th...

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Detalhes bibliográficos
Main Authors: Li, Yongqing, Liu, Baoling, Gu, Xuesong, Kochanek, Ashley R., Fukudome, Eugene Y., Liu, Zhengcai, Zhao, Ting, Chong, Wei, Zhao, Yili, Zhang, Dainan, Libermann, Towia A., Alam, Hasan B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782099/
https://ncbi.nlm.nih.gov/pubmed/22938904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2012.06.036
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