Hepatocyte Nuclear Factor 1 Regulates the Expression of the Organic Cation Transporter 1 via Binding to an Evolutionary Conserved Region in Intron 1 of the OCT1 Gene

The organic cation transporter 1 (OCT1), also known as solute carrier family 22 member 1, is strongly and specifically expressed in the human liver. Here we show that the hepatocyte nuclear factor 1 (HNF1) regulates OCT1 transcription and contributes to the strong, liver-specific expression of OCT1....

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Autors principals: O’Brien, Valerie P., Bokelmann, Kristin, Ramírez, Jacqueline, Jobst, Karoline, Ratain, Mark J., Brockmöller, Jürgen, Tzvetkov, Mladen V.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2013
Matèries:
Metabolism, Transport, and Pharmacogenomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781413/
https://ncbi.nlm.nih.gov/pubmed/23922447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.206359
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