Multimodal Interaction with BCL-2 Family Proteins Underlies the Pro-Apoptotic Activity of PUMA BH3

PUMA is a pro-apoptotic BCL-2 family member that drives the apoptotic response to a diversity of p53-dependent and independent cellular insults. Deciphering the spectrum of PUMA interactions that confer its context-dependent pro-apoptotic properties remains a high priority goal. Here, we report the...

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Main Authors: Edwards, Amanda L., Gavathiotis, Evripidis, LaBelle, James L., Braun, Craig R., Opoku-Nsiah, Kwadwo A., Bird, Gregory H., Walensky, Loren D.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781208/
https://ncbi.nlm.nih.gov/pubmed/23890007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.06.007
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