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Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation

TGFβ is secreted in a latent state and must be “activated” by molecules that facilitate its release from a latent complex and allow binding to high affinity cell surface receptors. Numerous molecules have been implicated as potential mediators of this activation process, but only a limited number of...

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Bibliografiske detaljer
Main Authors: Robertson, Ian B, Rifkin, Daniel B
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780968/
https://ncbi.nlm.nih.gov/pubmed/23849989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cytogfr.2013.06.003
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