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Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation
TGFβ is secreted in a latent state and must be “activated” by molecules that facilitate its release from a latent complex and allow binding to high affinity cell surface receptors. Numerous molecules have been implicated as potential mediators of this activation process, but only a limited number of...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3780968/ https://ncbi.nlm.nih.gov/pubmed/23849989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cytogfr.2013.06.003 |
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