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Latent TGF-β structure and activation
Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-β1 requires the binding of α(v) integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TG...
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| Publicat a: | Nature |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4717672/ https://ncbi.nlm.nih.gov/pubmed/21677751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10152 |
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