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Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion
The lymphocyte homing receptor integrin α(4)β(7) is unusual for its ability to mediate both rolling and firm adhesion. α(4)β(1) and α(4)β(7) are targeted by therapeutics approved for multiple sclerosis and Crohn’s disease. Here, we show by electron microscopy and crystallography how two therapeutic...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3255974/ https://ncbi.nlm.nih.gov/pubmed/22232704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201110023 |
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