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α(V)β(3) Integrin Crystal Structures and their Functional Implications

Many questions remain about the significance of structural features of integrin α(V)β(3) for its mechanism of activation. We have determined and re-refined, respectively, crystal structures of the α(V)β(3) ectodomain linked to C-terminal coiled-coils (α(V)β(3)-AB) or four transmembrane (TM) residues...

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Detalhes bibliográficos
Main Authors: Dong, Xianchi, Mi, Li-Zhi, Zhu, Jianghai, Wang, Wei, Hu, Ping, Luo, Bing-Hao, Springer, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495331/
https://ncbi.nlm.nih.gov/pubmed/23106217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300734n
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