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Requirement of α and β subunit transmembrane helix separation for integrin outside-in signaling
Adhesion to extracellular ligands through integrins regulates cell shape, migration, growth, and survival. How integrins transmit signals in the outside-to-in direction remains unknown. Whereas in resting integrins the α and β subunit transmembrane domains are associated, ligand binding promotes dis...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1988953/ https://ncbi.nlm.nih.gov/pubmed/17615290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-080077 |
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