Requirement of α and β subunit transmembrane helix separation for integrin outside-in signaling

Adhesion to extracellular ligands through integrins regulates cell shape, migration, growth, and survival. How integrins transmit signals in the outside-to-in direction remains unknown. Whereas in resting integrins the α and β subunit transmembrane domains are associated, ligand binding promotes dis...

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Autores principales: Zhu, Jieqing, Carman, Christopher V., Kim, Minsoo, Shimaoka, Motomu, Springer, Timothy A., Luo, Bing-Hao
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2007
Materias:
Hemostasis, Thrombosis, and Vascular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988953/
https://ncbi.nlm.nih.gov/pubmed/17615290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-080077
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