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Regulation of outside-in signaling and affinity by the β(2) I domain of integrin α(L)β(2)
The adhesiveness of integrin α(L)β(2) is modulated by divalent cations. We mutated three metal ion-binding sites in the β(2) I domain. The metal ion-dependent adhesion site (MIDAS) and the ligand-induced metal-binding site are required for ligand binding and sufficient for synergism between Ca(2+) a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1559753/ https://ncbi.nlm.nih.gov/pubmed/16920795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605666103 |
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