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Nonspecific bridging-induced attraction drives clustering of DNA-binding proteins and genome organization

Molecular dynamics simulations are used to model proteins that diffuse to DNA, bind, and dissociate; in the absence of any explicit interaction between proteins, or between templates, binding spontaneously induces local DNA compaction and protein aggregation. Small bivalent proteins form into rows [...

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Main Authors: Brackley, Chris A., Taylor, Stephen, Papantonis, Argyris, Cook, Peter R., Marenduzzo, Davide
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780866/
https://ncbi.nlm.nih.gov/pubmed/24003126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302950110
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