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Nonspecific bridging-induced attraction drives clustering of DNA-binding proteins and genome organization
Molecular dynamics simulations are used to model proteins that diffuse to DNA, bind, and dissociate; in the absence of any explicit interaction between proteins, or between templates, binding spontaneously induces local DNA compaction and protein aggregation. Small bivalent proteins form into rows [...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3780866/ https://ncbi.nlm.nih.gov/pubmed/24003126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302950110 |
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