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Temporally Overlapped but Uncoupled Motions in Dihydrofolate Reductase Catalysis

Temporal correlations between protein motions and enzymatic reactions are often interpreted as evidence for catalytically important motions. Using dihydrofolate reductase as a model system, we show that there are many protein motions that temporally overlapped with the chemical reaction, and yet the...

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Bibliographic Details
Main Authors: Liu, C. Tony, Wang, Lin, Goodey, Nina M., Hanoian, Philip, Benkovic, Stephen J.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779903/
https://ncbi.nlm.nih.gov/pubmed/23883151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400858m
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