The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase

Residues M42 and G121 of Escherichia coli dihydrofolate reductase (ecDHFR) are on opposite sides of the catalytic centre (15 and 19 Å away from it, respectively). Theoretical studies have suggested that these distal residues might be part of a dynamics network coupled to the reaction catalysed at th...

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Main Authors: Wang, Lin, Goodey, Nina M, Benkovic, Stephen J, Kohen, Amnon
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society 2006
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1647312/
https://ncbi.nlm.nih.gov/pubmed/16873118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2006.1871
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