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Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans
With the rapidly growing wealth of genomic data, experimental inquiries on the functional significance of important divergence sites in protein evolution are becoming more accessible. Here we trace the evolution of dihydrofolate reductase (DHFR) and identify multiple key divergence sites among 233 s...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690862/ https://ncbi.nlm.nih.gov/pubmed/23733948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307130110 |
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