Llwytho...

Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans

With the rapidly growing wealth of genomic data, experimental inquiries on the functional significance of important divergence sites in protein evolution are becoming more accessible. Here we trace the evolution of dihydrofolate reductase (DHFR) and identify multiple key divergence sites among 233 s...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liu, C. Tony, Hanoian, Philip, French, Jarrod B., Pringle, Thomas H., Hammes-Schiffer, Sharon, Benkovic, Stephen J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690862/
https://ncbi.nlm.nih.gov/pubmed/23733948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307130110
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