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Temporally Overlapped but Uncoupled Motions in Dihydrofolate Reductase Catalysis
Temporal correlations between protein motions and enzymatic reactions are often interpreted as evidence for catalytically important motions. Using dihydrofolate reductase as a model system, we show that there are many protein motions that temporally overlapped with the chemical reaction, and yet the...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3779903/ https://ncbi.nlm.nih.gov/pubmed/23883151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400858m |
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