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Temporally Overlapped but Uncoupled Motions in Dihydrofolate Reductase Catalysis
Temporal correlations between protein motions and enzymatic reactions are often interpreted as evidence for catalytically important motions. Using dihydrofolate reductase as a model system, we show that there are many protein motions that temporally overlapped with the chemical reaction, and yet the...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3779903/ https://ncbi.nlm.nih.gov/pubmed/23883151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400858m |
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