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A Free Energy Study of the Catalytic Mechanism of Trypanosoma cruzi Trans-Sialidase. From the Michaelis Complex to the Covalent Intermediate()
Trypanosoma cruzi trans -sialidase (TcTS) is a crucial enzyme for the infection of Trypanosoma cruzi, the protozoa responsible for Chagas’ disease in humans. It catalyzes the transfer of sialic acids from the host’s glycoconjugates to the parasite’s glycoconjugates. Based on kinetic isotope effect (...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3779645/ https://ncbi.nlm.nih.gov/pubmed/22007596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2009618 |
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