ASMASE IS REQUIRED FOR CHRONIC ALCOHOL INDUCED HEPATIC ENDOPLASMIC RETICULUM STRESS AND MITOCHONDRIAL CHOLESTEROL LOADING

BACKGROUND & AIMS: The pathogenesis of alcohol-induced liver disease (ALD) is poorly understood. Here, we examined the role of acid sphingomyelinase (ASMase) in alcohol induced hepatic endoplasmic reticulum (ER) stress, a key mechanism of ALD METHODS: We examined ER stress, lipogenesis, hyperhom...

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Autori principali: Fernandez, Anna, Matias, Núria, Fucho, Raquel, Ribas, Vicente, Von Montfort, Claudia, Nuño, Natalia, Baulies, Anna, Martinez, Laura, Tarrats, Núria, Mari, Montserrat, Colell, Anna, Morales, Albert, Dubuquoy, Laurent, Mathurin, Philippe, Bataller, Ramón, Caballeria, Joan, Elena, Montserrat, Balsinde, Jesus, Kaplowitz, Neil, Garcia-Ruiz, Carmen, Fernandez-Checa, Jose C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779525/
https://ncbi.nlm.nih.gov/pubmed/23707365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2013.05.023
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