Acidic Sphingomyelinase Controls Hepatic Stellate Cell Activation and in Vivo Liver Fibrogenesis

The mechanisms linking hepatocellular death, hepatic stellate cell (HSC) activation, and liver fibrosis are largely unknown. Here, we investigate whether acidic sphingomyelinase (ASMase), a known regulator of death receptor and stress-induced hepatocyte apoptosis, plays a role in liver fibrogenesis....

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Detalhes bibliográficos
Principais autores: Moles, Anna, Tarrats, Núria, Morales, Albert, Domínguez, Marlene, Bataller, Ramón, Caballería, Juan, García-Ruiz, Carmen, Fernández-Checa, José C., Marí, Montserrat
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928955/
https://ncbi.nlm.nih.gov/pubmed/20651240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091257
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