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Cathepsin B Overexpression Due to Acid Sphingomyelinase Ablation Promotes Liver Fibrosis in Niemann-Pick Disease

Niemann-Pick disease (NPD) is a lysosomal storage disease caused by the loss of acid sphingomyelinase (ASMase) that features neurodegeneration and liver disease. Because ASMase-knock-out mice models NPD and our previous findings revealed that ASMase activates cathepsins B/D (CtsB/D), our aim was to...

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Detalhes bibliográficos
Main Authors: Moles, Anna, Tarrats, Núria, Fernández-Checa, José C., Marí, Montserrat
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256848/
https://ncbi.nlm.nih.gov/pubmed/22102288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.272393
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