Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation

Sirtuin-1 (SIRT1) regulates hepatic metabolism but its contribution to NF-κB-dependent inflammation has been overlooked. Cysteine cathepsins (Cathepsin B or S, CTSB/S) execute specific functions in physiological processes, such as protein degradation, having SIRT1 as a substrate. We investigated the...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: de Mingo, Álvaro, de Gregorio, Estefanía, Moles, Anna, Tarrats, Núria, Tutusaus, Anna, Colell, Anna, Fernandez-Checa, Jose C, Morales, Albert, Marí, Montserrat
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260902/
https://ncbi.nlm.nih.gov/pubmed/27831566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.368
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