ASMASE REGULATES AUTOPHAGY AND LYSOSOMAL MEMBRANE PERMEABILIZATION AND ITS INHIBITION PREVENTS EARLY STAGE NONALCOHOLIC STEATOHEPATITIS

BACKGROUND & AIM: Acid sphingomyelinase (ASMase) is activated in nonalcoholic steatohepatitis (NASH). However, ASMase’s contribution to NASH is poorly understood and limited to hepatic steatosis and glucose metabolism. Here we examined ASMase’s role in high fat diet (HFD)-induced NASH. METHODS:...

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Hoofdauteurs: Fucho, Raquel, Martínez, Laura, Baulies, Anna, Torres, Sandra, Tarrats, Nuria, Fernandez, Anna, Ribas, Vicente, Astudillo, Alma M., Balsinde, Jesús, Garcia-Rovés, Pablo, Elena, Montserrat, Bergheim, Ina, Lotersztajn, Sophie, Trautwein, Christian, Appelqvist, Hanna, Paton, Adrienne W., Paton, James C., Czaja, Mark J., Kaplowitz, Neil, Fernandez-Checa, Jose C., García-Ruiz, Carmen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203709/
https://ncbi.nlm.nih.gov/pubmed/24946279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2014.06.009
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