ASMASE REGULATES AUTOPHAGY AND LYSOSOMAL MEMBRANE PERMEABILIZATION AND ITS INHIBITION PREVENTS EARLY STAGE NONALCOHOLIC STEATOHEPATITIS

BACKGROUND & AIM: Acid sphingomyelinase (ASMase) is activated in nonalcoholic steatohepatitis (NASH). However, ASMase’s contribution to NASH is poorly understood and limited to hepatic steatosis and glucose metabolism. Here we examined ASMase’s role in high fat diet (HFD)-induced NASH. METHODS:...

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Päätekijät: Fucho, Raquel, Martínez, Laura, Baulies, Anna, Torres, Sandra, Tarrats, Nuria, Fernandez, Anna, Ribas, Vicente, Astudillo, Alma M., Balsinde, Jesús, Garcia-Rovés, Pablo, Elena, Montserrat, Bergheim, Ina, Lotersztajn, Sophie, Trautwein, Christian, Appelqvist, Hanna, Paton, Adrienne W., Paton, James C., Czaja, Mark J., Kaplowitz, Neil, Fernandez-Checa, Jose C., García-Ruiz, Carmen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203709/
https://ncbi.nlm.nih.gov/pubmed/24946279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2014.06.009
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