Glucose deprivation is associated with Chk1 degradation through the ubiquitin-proteasome pathway and effective checkpoint response to replication blocks

Chk1 plays a key role in the DNA replication checkpoint and in preserving genomic integrity. Previous studies have shown that reduced Chk1 function leads to defects in the checkpoint response and is closely associated with tumorigenesis. Here, we report that glucose deprivation caused the degradatio...

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Bibliographische Detailangaben
Hauptverfasser: Kim, Ae Jeong, Kim, Hyun-Ju, Jee, Hye Jin, Song, Naree, Kim, Minjee, Bae, Yoe-Sik, Chung, Jay H., Yun, Jeanho
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779427/
https://ncbi.nlm.nih.gov/pubmed/21440578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2011.03.012
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