Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation

BACKGROUND: Aberrant activation of DNA damage response (DDR) is a major cause of chemoresistance in colorectal cancer (CRC). CHK1 is upregulated in CRC and contributes to therapeutic resistance. We investigated the upstream signaling pathways governing CHK1 activation in CRC. METHODS: We identified...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Yu, Xinfang, Li, Wei, Liu, Haidan, Deng, Qipan, Wang, Xu, Hu, Hui, Xu-Monette, Zijun Y., Xiong, Wei, Lu, Zhongxin, Young, Ken H., Wang, Wei, Li, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7193419/
https://ncbi.nlm.nih.gov/pubmed/32357935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-020-00869-3
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