NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1

Ubiquitin (Ub)-mediated proteasome-dependent proteolysis is critical in regulating multiple biological processes including apoptosis. We show that the unstructured BH3-only protein, NOXA, is degraded by an Ub-independent mechanism requiring 19S regulatory particle (RP) subunits of the 26S proteasome...

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Detalhes bibliográficos
Main Authors: Craxton, A, Butterworth, M, Harper, N, Fairall, L, Schwabe, J, Ciechanover, A, Cohen, G M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422467/
https://ncbi.nlm.nih.gov/pubmed/22361683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.16
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