Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism

During transcription elongation, RNA polymerase has been assumed to attain equilibrium between pre- and post-translocated states rapidly relative to the subsequent catalysis. Under this assumption, recent single-molecule studies proposed a branched Brownian ratchet mechanism that necessitates a puta...

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Bibliografiske detaljer
Main Authors: Dangkulwanich, Manchuta, Ishibashi, Toyotaka, Liu, Shixin, Kireeva, Maria L, Lubkowska, Lucyna, Kashlev, Mikhail, Bustamante, Carlos J
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2013
Fag:
Biophysics and Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778554/
https://ncbi.nlm.nih.gov/pubmed/24066225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00971
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