Ultra-sensitive fluorescent proteins for imaging neuronal activity

Fluorescent calcium sensors are widely used to image neural activity. Using structure-based mutagenesis and neuron-based screening, we developed a family of ultra-sensitive protein calcium sensors (GCaMP6) that outperformed other sensors in cultured neurons and in zebrafish, flies, and mice in vivo....

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Bibliografski detalji
Glavni autori: Chen, Tsai-Wen, Wardill, Trevor J., Sun, Yi, Pulver, Stefan R., Renninger, Sabine L., Baohan, Amy, Schreiter, Eric R., Kerr, Rex A., Orger, Michael B., Jayaraman, Vivek, Looger, Loren L., Svoboda, Karel, Kim, Douglas S.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777791/
https://ncbi.nlm.nih.gov/pubmed/23868258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12354
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