A Neuron-Based Screening Platform for Optimizing Genetically-Encoded Calcium Indicators

Fluorescent protein-based sensors for detecting neuronal activity have been developed largely based on non-neuronal screening systems. However, the dynamics of neuronal state variables (e.g., voltage, calcium, etc.) are typically very rapid compared to those of non-excitable cells. We developed an e...

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Detalles Bibliográficos
Main Authors: Wardill, Trevor J., Chen, Tsai-Wen, Schreiter, Eric R., Hasseman, Jeremy P., Tsegaye, Getahun, Fosque, Benjamin F., Behnam, Reza, Shields, Brenda C., Ramirez, Melissa, Kimmel, Bruce E., Kerr, Rex A., Jayaraman, Vivek, Looger, Loren L., Svoboda, Karel, Kim, Douglas S.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796516/
https://ncbi.nlm.nih.gov/pubmed/24155972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077728
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