A Neuron-Based Screening Platform for Optimizing Genetically-Encoded Calcium Indicators

Fluorescent protein-based sensors for detecting neuronal activity have been developed largely based on non-neuronal screening systems. However, the dynamics of neuronal state variables (e.g., voltage, calcium, etc.) are typically very rapid compared to those of non-excitable cells. We developed an e...

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Main Authors: Wardill, Trevor J., Chen, Tsai-Wen, Schreiter, Eric R., Hasseman, Jeremy P., Tsegaye, Getahun, Fosque, Benjamin F., Behnam, Reza, Shields, Brenda C., Ramirez, Melissa, Kimmel, Bruce E., Kerr, Rex A., Jayaraman, Vivek, Looger, Loren L., Svoboda, Karel, Kim, Douglas S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796516/
https://ncbi.nlm.nih.gov/pubmed/24155972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077728
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