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Ultra-sensitive fluorescent proteins for imaging neuronal activity
Fluorescent calcium sensors are widely used to image neural activity. Using structure-based mutagenesis and neuron-based screening, we developed a family of ultra-sensitive protein calcium sensors (GCaMP6) that outperformed other sensors in cultured neurons and in zebrafish, flies, and mice in vivo....
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3777791/ https://ncbi.nlm.nih.gov/pubmed/23868258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12354 |
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