Ultra-sensitive fluorescent proteins for imaging neuronal activity

Fluorescent calcium sensors are widely used to image neural activity. Using structure-based mutagenesis and neuron-based screening, we developed a family of ultra-sensitive protein calcium sensors (GCaMP6) that outperformed other sensors in cultured neurons and in zebrafish, flies, and mice in vivo....

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Detalhes bibliográficos
Main Authors: Chen, Tsai-Wen, Wardill, Trevor J., Sun, Yi, Pulver, Stefan R., Renninger, Sabine L., Baohan, Amy, Schreiter, Eric R., Kerr, Rex A., Orger, Michael B., Jayaraman, Vivek, Looger, Loren L., Svoboda, Karel, Kim, Douglas S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777791/
https://ncbi.nlm.nih.gov/pubmed/23868258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12354
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